When Beatlemania burst forth in the early 60's, Harold and Louise Harrison responded warmly to the multitude of Beatle fans worldwide who wrote letters to and about their son, thus becoming Mum and Dad to a warm and loving Global Family of Beatle People. During 1964 and 1965 Louise, living in Illinois, found herself writing and broadcasting daily Beatle reports nationwide, due to public demand for news of The Beatles. Her distinctive voice with its British accent is immediately recognized by Beatle People all over the world. She has made hundreds of public appearances to greet and hug Beatle People all over the U.S., Europe, Canada and Mexico. When her parents died in the late 1970s, Louise became Mum, known by many as "the flying mum," to what she fondly refers to as her Global Family.

Louise has been on dozens of TV shows. Internationally, she has been seen on CNN's Larry King Live, Aaron Brown, Paula Zahn and Talk Back Live. Nationally , she has appeared on The Today Show, Good Morning America and many more.

As for radio, besides hosting her own radio talk show in the late 1960's, Louise has been a guest on dozens of other radio shows. Worldwide, countless newspaper articles  have been written with Louise as the subject. She also has been featured in magazines such as Rolling Stone, People and Modern Maturity.

During the 1990's Louise founded and ran "DROP-IN", an environmental not-for-profit organization. The World Watch Institute and The Union of Concerned Scientists both worked closely with Louise, giving advice as she researched, wrote and broadcast 170 Public Service Announcements (PSAs) (backed by George's song "Save the World") which she called Good Earth Keeping tips. These PSAs ran for about 18 months on 9,200 Westwood One & ABC Oldies Satellite radio stations in the U.S. during 1993 & 1994.

Over the years, Louise has appeared at Beatle events all over the U.S., Canada, Mexico , Europe and Argentina. An eloquent and gifted public speaker, Louise has spoken at Colleges and Schools, Conventions, Corporate Functions and Service Organizations, as well as fundraisers for many other Charities.

In 2005 Louise formed Louise Harrison Entertainment, LTD. Its goal was to create, introduce and manage a new Beatles Tribute band, Liverpool Legends. Having worked with the band to incorporate many ideas from conversations she had with her brother, Louise believes that this is the kind of band with whom George would have enjoyed playing.

The members of Liverpool Legends enjoy each other's company with no ego trips, play a wide variety of Beatle and individual Beatle music, as well as some of their personal favorites. Both management and the band are dedicated to upholding and continuing the positive impact of the Beatles on the Planet. When her tight schedule permits, Louise occasionally appears with the band. In addition to interactive chats with the audience, she also gives spoken interpretations of some of her brother's most meaningful songs.